ArticleInternational journal of legal medicine2026
Postmortem metabolomics as a window into the agonal phase of death: a comparison between opioid intoxications and hangings.
Article in International journal of legal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fatal opioid intoxications provide a postmortem diagnostic challenge due to a lack of coherent autopsy findings and the potential of tolerance and individual variations to complicate the evaluation of toxicological results. This study investigates whether postmortem metabolomics could be used to discriminate between opioid intoxications, irrespective of the involved opioid, and hangings, and if the degree of respiratory failure in intoxications could be predicted. Data was acquired from toxicological screenings of femoral blood with high resolution mass spectrometry (HRMS) comprising 338 hangings and 287 opioid intoxications. Cases were divided into a training set and a validation set using a 3:1 ratio. An orthogonal partial least squares discriminant analysis (OPLS-DA) binary classification model was built using 269 features, with an R
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