Evidence map›Paper›PMID 42658226›Full record

ArticleNeuroradiology2026

Retrospective cohort analysis of early post treatment follow-up MRI biomarkers of collateral status associated with long-term outcomes in large vessel occlusion acute ischemic stroke.

Cynthia Greene, Hamza Adel Salim, Dhairya A Lakhani, Andrew Cho, Derek Tsang, Karthik Lalwani, Meisam Hoseinyazdi, Sijin Wen, Jeremy J Heit, Tobias D Faizy and 11 more

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Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Cynthia Greene *Johns Hopkins Medical Center, Baltimore, US.
Hamza Adel Salim *Department of Radiology, The University of Texas Medical Branch, Galveston, US. Hamza.sleeem@gmail.com.ORCID http://orcid.org/0000-0002-5208-8425
Dhairya A LakhaniWest Virginia University, Morgantown, US.ORCID https://orcid.org/0000-0001-7577-1887
Andrew ChoJohns Hopkins Medical Center, Baltimore, US.
Derek TsangJohns Hopkins Medical Center, Baltimore, US.
Karthik LalwaniJohns Hopkins Medical Center, Baltimore, US.
Meisam HoseinyazdiJohns Hopkins Medical Center, Baltimore, US.
Sijin WenWest Virginia University, Morgantown, US.
Jeremy J HeitStanford Medical Center, Palo Alto, US.
Tobias D FaizyUniversity Medical Center, Münster, Germany.
Gaurang ShahUniversity of Michigan, Ann Arbor, US.
Aakanksha SriwastwaUniversity of Cincinnati, Cincinnati, US.
Yasmin AzizUniversity of Cincinnati Medical Center, Cincinnati, US.ORCID https://orcid.org/0000-0002-3515-4005
Gregory W AlbersStanford Medical Center, Palo Alto, US.
Shyam MajmundarUniversity of Maryland Medical Center, Baltimore, US.
Adrien GuenegoErasme University Hospital, Brussels, Belgium.ORCID https://orcid.org/0000-0001-7281-1652
Adam A DmytriwMassachusetts General Hospital & Brigham, Harvard Medical School, Boston, US.ORCID https://orcid.org/0000-0003-0131-5699
Hanzhang LuJohns Hopkins Medical Center, Baltimore, US.
Risheng XuJohns Hopkins Medical Center, Baltimore, US.ORCID https://orcid.org/0000-0003-4288-1232
David S LiebeskindUCLA Stroke Center, University of Southern California, Los Angeles, US.
Vivek YedavalliJohns Hopkins Medical Center, Baltimore, US. vyedava1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeFLAIR hyperintense vessels (FHV) on MRI, quantified using the NIH-FHV score (NFS), is associated with altered hemodynamics in acute ischemic stroke (AIS). We aimed to evaluate the long-term prognostic significance of post-treatment NFS in patients with anterior circulation large vessel occlusion (AIS-LVO). MATERIALS AND

methodsWe retrospectively analyzed 279 AIS-LVO patients with in-hospital follow-up MRI. NFS were evaluated and correlated with modified Rankin Score at 90-days (mRS-90) ≤ 2 as a long-term clinical outcome. Spearman correlation and logistic regression models were generated. A bidirectional algorithm based on Akike criteria was used to select clinical and imaging covariates in the final model. Analyses were repeated in all patients who underwent mechanical thrombectomy (MT) and a successfully reperfused subgroup (mTICI ≥2b).

resultsNFS was observed in 39% of the cases examined. All cohorts retained NFS as a significant predictor of unfavorable mRS 90, All treatment (OR 0.724, p < 0.01), All MT (OR 0.595, P < 0.01) and MT2b (OR 0.624, P = 0.02). All treatment multivariable regression model with NFS demonstrated an AUC of 0.867 compared to the covariates alone of 0.850, statistically significant by the Delong test, p = 0.047.

conclusionsNFS on post-treatment MRI is a robust imaging biomarker of persistent perfusion deficits and associated with decreased likelihood of successful long-term outcomes even after successful reperfusion.

Indexed as

Collateral CirculationIschemic StrokeMagnetic Resonance ImagingAgedBiomarkersFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesThrombectomyTreatment OutcomeBiomarkersCerebral infarctionCollateral circulationFLAIR hyperintense vesselsMagnetic resonance imagingNo-reflow phenomenonPrognosisThrombectomy

Identifiers

PMID42658226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.