ArticleBioMed research international2026
Aflatoxin B1 Disrupts Ovarian Follicular Dynamics and Activates Intrinsic Apoptosis-Related Signaling in Rat Ovaries: Interactions Between Hormonal Imbalance and Follicular Atresia.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAflatoxin B1 (AFB1) is one of the most potent naturally occurring mycotoxins and has been implicated in reproductive toxicity. The present study is aimed at evaluating the time-dependent effects of experimental AFB1 exposure on ovarian follicular dynamics, reproductive hormone profiles, and intrinsic apoptosis-related markers in female rats. METHODOLOGY: Twenty-four mature female Wistar rats were assigned to control and AFB1-exposed groups (N = 6 per time point). AFB1 was administered intraperitoneally at 20 mg/kg body weight for 7, 14, and 21 days. Ovarian tissue and serum samples were collected at the end of each designated exposure period. Follicular population and atresia were evaluated histologically; serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and progesterone were measured by ELISA, and the expression patterns of Bcl-2, Bax, p53, and caspase-3 were assessed using RT-PCR and immunohistochemistry.
resultsAFB1 exposure was associated with a time-dependent reduction in total follicular population and a marked increase in follicular atresia. Serum FSH, LH, estrogen, and progesterone concentrations were significantly decreased in AFB1-exposed animals compared with controls. At the molecular level, AFB1 decreased Bcl-2 expression while increasing Bax, p53, and caspase-3 expression in ovarian tissue, with prominent immunoreactivity in follicular cells.
conclusionThese findings indicate that experimental AFB1 exposure is associated with impaired follicular development, endocrine disruption, and activation of intrinsic apoptosis-related signaling in rat ovaries. The observed coordinated changes suggest a biologically plausible interaction between hormonal imbalance and apoptosis-associated pathways in AFB1-induced follicular atresia, although functional validation is required to confirm direct causal mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.