Evidence map›Paper›PMID 42657663›Full record

ReviewComprehensive reviews in food science and food safety2026

Natural Pigments and Cyclodextrins: Overview on a Synergistic Approach to Encapsulation.

Chiara Pippolini, Ilaria Benucci, Claudio Lombardelli, Marco Esti

Abstract readReview
In one paragraph

Review in Comprehensive reviews in food science and food safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chiara PippoliniDepartment of Agriculture and Forestry Science (DAFNE), Tuscia University, Viterbo, Italy.
Ilaria BenucciDepartment of Agriculture and Forestry Science (DAFNE), Tuscia University, Viterbo, Italy.ORCID https://orcid.org/0000-0001-7114-8641
Claudio LombardelliDepartment of Agriculture and Forestry Science (DAFNE), Tuscia University, Viterbo, Italy.ORCID https://orcid.org/0000-0003-4325-6658
Marco EstiDepartment of Agriculture and Forestry Science (DAFNE), Tuscia University, Viterbo, Italy.

Funding

Ministry of University and Research (MUR)
6 · The paper itself

Abstract

The growing demand for natural dyes in the food industry has stimulated research into strategies aimed at improving their stability, solubility, and bioavailability. This review examines the synergistic use of cyclodextrins (CDs) as encapsulating agents for natural pigments, highlighting their ability to form inclusion complexes that protect pigments from various external factors. Following an overview of the structure, chemistry, and functionalization of CDs, their role in stabilizing different classes of natural pigments is discussed. Among the various types, β-CD emerges as the most widely used due to its optimal cavity size and commercial availability. The main encapsulation techniques, along with the analytical methods used to characterize the resulting complexes, are also presented. Finally, several studies are reviewed, confirming that CDs significantly enhance the physicochemical properties and solubility of natural pigments, thereby supporting their application in food matrices with results comparable to those of synthetic dyes.

Indexed as

CyclodextrinsFood Coloring AgentsPigments, BiologicalColoring AgentsSolubilityColoring AgentsCyclodextrinsFood Coloring AgentsPigments, Biologicalcyclodextrinsencapsulationinclusion complexnatural dyesstability

Identifiers

PMID42657663
PMCPMC13520132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.