Evidence map›Paper›PMID 42657649›Full record

ArticleClinical and experimental immunology2026

Prospective association between leukocyte telomere length and mortality: findings from the Black Women's Experiences Living with Lupus (BeWELL) Study.

David H Chae, Connor D Martz, Amani M Nuru-Jeter, Tiffany Yip, Jue Lin, Eloisa Bonfá, Elissa S Epel, Kenneth Saag, Cristina M Lanata, Sofia Nadgauda and 2 more

Abstract read
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In one paragraph

Article in Clinical and experimental immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David H ChaeDepartment of Social, Behavioral, and Population Sciences, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Connor D MartzDepartment of Population Health Sciences, University of Central Florida, College of Medicine, Orlando, FL, USA.
Amani M Nuru-JeterDepartment of Community Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Tiffany YipDepartment of Psychology, Fordham University, New York City, NY, USA.ORCID 0000-0001-7488-533X
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Eloisa BonfáHospital das Clinicas HCFMUSP, Faculdade de Medicina, Rheumatology Division, Universidade de Sao Pãulo, Sao Pãulo, Brazil.ORCID 0000-0002-0520-4681
Elissa S EpelDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9334-4720
Kenneth SaagDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Cristina M LanataNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Sofia NadgaudaDepartment of Social, Behavioral, and Population Sciences, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.ORCID 0009-0003-5576-8148
Jesus Ramirez-VallesDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jinoos YazdanyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3508-4094

Funding

Training Program in Population StudiesT32HD007081 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI Aprile Dawn Benner, Abigail Mae Weitzman · 1985 to 2026
$6.8M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Catherine A Calder · 2017 to 2026
$5.2M
Psychosocial Factors and Lupus Disease Progression Among African American WomenR01AR065493 · NIAMS · UNIV OF MARYLAND, COLLEGE PARK · PI CHAE, H. DAVID, LIM, SUNG SAM · 2014 to 2022
$4.2M
Biopsyochosocial Mechanisms of Lupus Progression in African American WomenF31AR076234 · NIAMS · AUBURN UNIVERSITY AT AUBURN · PI MARTZ, CONNOR D. · 2019 to 2020
$78k
Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health P2CHD042849Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health T32HD007081NIAMS NIH HHS F31 AR076234NIAMS NIH HHS R01 AR065493NICHD NIH HHS P2C HD042849NICHD NIH HHS T32 HD007081NIH HHS F31AR076234NIH HHS R01AR065493
6 · The paper itself

Abstract

Leukocyte telomere length (LTL) is a biomarker of replicative history of cells and has been posited to be an indicator of biological aging. LTL may yield insight into immunomodulatory disorders, including systemic lupus erythematosus (SLE), an immune-mediated inflammatory disease that disproportionately affects Black/African American women. This study examined the association between LTL and mortality among 422 Black/African American women in the Black Women's Experiences Living with Lupus (BeWELL) Study. Participants were recruited from metropolitan Atlanta, Georgia, between April 2015 and May 2017 and followed for a mean of 1.98 years (SD = 0.38). LTL was measured as the telomere-to-single copy gene ratio (T/S). Mortality was assessed prospectively. Cox proportional hazards regression models adjusting for sociodemographic, health, and disease characteristics were specified. A total of 19 participants died during the follow-up period. Adjusting for demographic, socioeconomic, and health-related covariates, longer LTL was associated with lower risk of mortality (hazard ratio = 0.13, 95% confidence interval = 0.02, 0.83, P = 0.03). This study is the first to report an association between LTL and subsequent mortality among Black/African American women with SLE. Findings may be particularly relevant for this population, which has been shown to experience severe disease consequences. Future research may further explore LTL in mechanistic studies of SLE and assess the utility of LTL for monitoring disease progression and outcomes.

Indexed as

Black or African AmericanLeukocytesLupus Erythematosus, SystemicTelomereAdultFemaleGeorgiaHumansMiddle AgedProspective StudiesBlack/African American womenleukocyte telomere lengthsurvival analysissystemic lupus erythematosus

Identifiers

PMID42657649
PMCPMC13575686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.