ArticleAdvanced healthcare materials2026
Quantification of Phosphorylated Tau Protein in Alzheimer's Disease Patients' Fluids With Electrolyte-Gated Organic Transistor Biosensors.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dementia is a syndrome that affects millions of people in the world, and Alzheimer's disease (AD) is the most common cause. The diagnosis of AD begins with cognitive symptoms such as mild cognitive impairment (MCI) but requires the demonstration and quantification of the underlying neuropathological processes through the measurement of specific biomarkers. Among these, the phosphorylated tau protein at threonine 181 (p-tau 181) is considered specific for AD diagnosis in people with MCI. In this work, we report the detection of p-tau 181 spanning from physiological to pathological concentrations in cerebrospinal fluids from patients with MCI. The proposed sensor is based on an electrolyte-gated organic transistor functionalized with specific anti-p-tau 181 antibodies. We analyzed the multiparametric sensor response using a Langmuir model to extract the thermodynamic affinity constant, resulting in values between 10
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