ArticleThe New phytologist2026
Dual localization of PDI5 couples endoplasmic reticulum proteostasis to meristem organization and meiotic fidelity in Arabidopsis.
Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Plant growth and reproduction require coordinated control of hormone-dependent tissue patterning and faithful meiotic chromosome segregation, yet whether upstream proteostasis contributes to both processes remains unclear. Here, we show that Arabidopsis PROTEIN DISULFIDE ISOMERASE 5 (PDI5) contributes to auxin-associated developmental patterning and meiotic fidelity. Native-promoter reporter constructs corresponding to two annotated PDI5 transcript isoforms show distinct subcellular enrichment, with one displaying an endoplasmic reticulum (ER)-associated distribution and the other showing nuclear enrichment. Disruption of PDI5 alters bulk glycoprotein staining and glycoside and trafficking-associated transcriptional programs, reduces the abundance of PIN-FORMED 2-green fluorescent protein (PIN2-GFP), alters its brefeldin A-sensitive intracellular accumulation, and is associated with perturbed auxin-response patterning and disorganized root meristems. In reproductive tissues, the pdi5 mutant shows abnormal germline-associated cell-fate restriction, impaired meiotic chromosome behavior, reduced chiasma formation and decreased fertility. Proteomic and interaction analyses identify the cohesin subunit SISTER-CHROMATID COHESION PROTEIN 3 (SCC3) as a PDI5-associated protein, and disruption of a conserved SCC3 N809-centered motif reduces its detectable association with PDI5. In a PDI5 promoter-driven conditional complementation assay, SCC3^N809E fails to support fertility rescue. These findings support a model in which PDI5-dependent proteostasis contributes to auxin-associated developmental patterning and meiotic chromosome fidelity, potentially through compartmentally distributed PDI5 functions.
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