ArticleDementia & neuropsychologia2026
Association of diabetes, hypertension and obesity with cognitive impairment in adults.
Article in Dementia & neuropsychologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cognitive impairment (CI) is prevalent in aging and affects the functionality and autonomy of individuals. Previous studies have demonstrated its association with metabolic diseases such as diabetes Objective: To investigate the association between DM, SAH, hypercholesterolemia and obesity and CI in adults aged 50 years or older. Methods: Cross-sectional population-based study using data from the second wave of the Brazilian longitudinal study of aging - ELSI-Brazil (2019). A total of 6,449 participants with complete data on the variables of interest and who responded directly to the survey were included in the analysis. CI was defined using standardized test z-scores. Exposures were identified through self-reported medical diagnoses and waist circumference measurements. Results: The combination of DM, hypertension, and obesity was associated with a 4% increase in the prevalence of CI. With the addition of hypercholesterolemia, this increase reached 10%. The isolated or combined presence of only two of these conditions was not associated with significant differences. Conclusion: Among people aged 50 and over, CI is more prevalent in those with multiple metabolic alterations. In a scenario of aging and high burden of chronic diseases, the findings reinforce the urgency of integrated prevention and control strategies to contain CI.
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