Evidence map›Paper›PMID 42657393›Full record

ArticleFASEB bioAdvances2026

Supraphysiological 25-Hydroxyvitamin D

Hoi Ching Cherry Chan, Sachin Bhoora, Esther Zhou, Sumari Marais, Tahir S Pillay, Rivak Punchoo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB bioAdvances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hoi Ching Cherry ChanDepartment of Chemical Pathology, Faculty of Health Sciences University of Pretoria Pretoria South Africa.ORCID https://orcid.org/0009-0008-8858-8633
Sachin BhooraVitamin D Cancer Group, Division of Chemical Pathology, Department of Pathology, Faculty of Health Sciences University of Cape Town Cape Town South Africa.ORCID https://orcid.org/0000-0001-7050-4974
Esther ZhouVitamin D Cancer Group, Division of Chemical Pathology, Department of Pathology, Faculty of Health Sciences University of Cape Town Cape Town South Africa.ORCID https://orcid.org/0000-0003-3652-1193
Sumari MaraisDepartment of Physiology, Faculty of Health Sciences University of Pretoria Pretoria South Africa.ORCID https://orcid.org/0000-0002-3953-227X
Tahir S PillayDepartment of Chemical Pathology, Faculty of Health Sciences University of Pretoria Pretoria South Africa.ORCID https://orcid.org/0000-0002-9982-9710
Rivak PunchooDepartment of Chemical Pathology, Faculty of Health Sciences University of Pretoria Pretoria South Africa.ORCID https://orcid.org/0000-0003-1570-3959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer remains a major global health challenge, necessitating continued advances in therapeutic strategies. Emerging evidence suggests that vitamin D derivatives may exert anti-cancer effects, including induction of apoptosis, potentially through redox-dependent mechanisms. This study investigated whether vitamin D exposure is associated with reactive oxygen species (ROS) accumulation, mitochondrial dysfunction, and apoptosis in cervical cancer cells. HeLa cells were exposed to physiological, intermediate, and supraphysiological concentrations of 25-hydroxyvitamin D

Indexed as

25‐hydroxycholecalciferolapoptosiscalcipotriolcervical canceroxidative stressreactive oxygen speciesvitamin D

Identifiers

PMID42657393
PMCPMC13513198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.