ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2026
Association of Janus kinase 1 and 2 expression with clinical indices in diabetic kidney disease.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diabetic Kidney Disease (DKD) is a prevalent complication of uncontrolled hyperglycemia that imposes a considerable burden on the health system due to the need for renal replacement therapy in the long term. Therefore, early diagnosis and prevention of renal damage in diabetic patients is critical. In the present study, we investigated the expression level of Janus kinase (Jak) 1, 2, and 3 genes, which play a role in the signal transduction of inflammatory cytokines and growth factors, for therapeutic or diagnostic purposes. Materials and Methods: Sixty patients with DKD, 60 diabetic patients without nephropathy, and 60 healthy individuals were recruited, and the expression level of the Jak1, Jak2, and Jak3 genes was evaluated using real-time polymerase chain reaction in peripheral blood mononuclear cells. Results: The results showed that Jak1 and Jak2 gene expression was significantly upregulated in DKD patients compared to healthy controls ( Conclusion: Gene expression evaluation showed an increased expression of Jak1 and Jak2 in DKD, suggesting Jak1/2 inhibition for the treatment of patients. In addition, Jak2 expression might have diagnostic or predictive value in diabetes.
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