ArticleJournal of translational internal medicine2026
Multidimensional physiological impairments are associated with frailty and survival in older patients with cancer.
Article in Journal of translational internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Background and Objectives: Frailty, which is influenced by the intricate interactions between malnutrition, metabolism, and systemic inflammation, is highly prevalent in the elderly and constitutes a significant barrier to the effective treatment of older patients with cancer. Assessing specific biomarker patterns may enhance our understanding of the mechanisms underlying the intricate networks that contribute to frailty in this population. This study aimed to examine the association between frailty and malnutrition, metabolism, and systemic inflammation in older patients with cancer, and to further assess their prognostic value. Methods: This multicenter cohort study included 2219 older patients with cancer categorized as non-frail ( Results: Three PCs were identified among 18 variables. PC1 represented a malnutrition-associated pattern. PC2 represented a metabolism-associated pattern. PC4 represented an inflammation-associated pattern. PC3 was excluded because of its redundancy with PC1. Frail patients exhibited significantly higher factor scores compared to pre-frail and robust patients in PC1 (median [IQR]: 1.03 [1.82] Conclusions: Frailty is significantly associated with decreased survival in older patients with cancer and coexists with multidimensional physiological impairments, including nutritional deficits, metabolic disturbances, and systemic inflammation.
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