ReviewThe MAK collection for occupational health and safety2026
p-Chloroaniline - Derivation of a BAR: Assessment Values in Biological Material - Translation of the German version from 2026.
Review in The MAK collection for occupational health and safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Human Biomonitoring of Butylated Hydroxytoluene (BHT) in Germany: Methods, Exposure Levels, and Health-Based Interpretation.La Medicina del lavoro · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area evaluated the data for 4-chloroaniline [106-47-8] to derive a biological reference value (BAR). p-Chloroaniline is an intermediate in organic synthesis and is used in the manufacture of pharmaceuticals, plant protection products and dyes. As a potent inducer of methaemoglobin formation, the hazards regarding its acute toxicity surpass the carcinogenic potential. Hence, several accidents with a consecutive cyanosis are reported. Besides the methaemoglobin level, two other, more specific biomarkers are known: p-chloroaniline set free from the haemoglobin adduct and p-chloroaniline in urine. p-Chloroaniline after hydrolysis represents the sum of all
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.