Evidence map›Paper›PMID 42657323›Full record

Trial reportResearch and practice in thrombosis and haemostasis2026

Relationship between sociodemographic characteristics at presentation and outcomes of provoked venous thromboembolism in United States children: a secondary analysis of the multinational Kids-duration of therapy for thrombosis trial.

Hope P Wilson, Maua M Alleyne, Sanjay Ahuja, Ernest Amankwah, Aisha Bruce, Shannon L Carpenter, Fernando F Corrales-Medina, Craig A Mullen, Arun Panigrahi, Lakshmi Srivaths and 5 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00687882 (Prospective Multi-Center Evaluation of the Duration of Therapy for Thrombosis in Children), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00687882 phase3completednot on this map

Prospective Multi-Center Evaluation of the Duration of Therapy for Thrombosis in Children

TypeinterventionalSponsorJohns Hopkins All Children's HospitalRan2008 to 2022Enrolled532ConditionsVenous ThrombosisArmsShortened duration (6 weeks) of anticoagulant therapy, Conventional duration (3 months) of anticoagulant therapy, No Intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hope P WilsonDivision of Hematology/Oncology, Department of Pediatrics, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Maua M AlleyneJohns Hopkins All Children's Institute for Clinical and Translational Research, St. Petersburg, Florida, USA.
Sanjay AhujaIndiana Hemophilia & Thrombosis Center, Indianapolis, Indiana, USA.
Ernest AmankwahDepartments of Pediatrics and Oncology, Johns Hopkins University School of Medicine, St. Petersburg, Florida, USA.
Aisha BruceDivision of Pediatric Hematology/Oncology, University of Alberta, Edmonton, Alberta, Canada.
Shannon L CarpenterDivision of Pediatric Hematology/Oncology/BMT, Children's Mercy Hospital, Kansas City, Missouri, USA.
Fernando F Corrales-MedinaDivision of Pediatric Hematology/Oncology, University of Miami Hemophilia and Thrombosis Comprehensive Treatment Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Craig A MullenDivision of Pediatric Hematology/Oncology, University of Rochester, Rochester, New York, USA.
Arun PanigrahiDivision of Pediatric Hematology/Oncology, University of California Davis, Davis, California, USA.
Lakshmi SrivathsDivision of Pediatric Hematology/Oncology, McGovern Medical School at UTHealth, Houston, Texas, USA.
Courtney D ThornburgDivision of Pediatric Hematology/Oncology, Rady Children's Health Orange County, Orange, California, USA.
Anupam VermaDepartment of Pediatrics, University of Utah, Primary Children's Hospital, Salt Lake City, Utah, USA.
Gary WoodsDivision of Pediatric Hematology/Oncology, Emory University School of Medicine, Children's Hospital of Atlanta, Atlanta, Georgia, USA.
Neil A GoldenbergJohns Hopkins All Children's Institute for Clinical and Translational Research, St. Petersburg, Florida, USA.
Madhvi RajpurkarDepartment of Pediatrics, Central Michigan University, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan, USA.

Funding

KidsDOTT-CCCU01HL130048 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GOLDENBERG, NEIL A · 2016 to 2021
$3.1M
NHLBI NIH HHS U01 HL130048
6 · The paper itself

Abstract

Background: Venous thromboembolism (VTE) is associated with adverse long-term sequelae, including recurrence and development of chronic venous insufficiency following limb deep vein thrombosis (postthrombotic syndrome [PTS]). Adult VTE studies have demonstrated that lower socioeconomic status, Black race, and Latinx ethnicity are associated with an increased risk of recurrence. Clinical trial-derived pediatric VTE data are limited. Objectives: The objective of this study was to assess whether clinical features of provoked VTE and outcomes vary across sociodemographic characteristics and proxies for social determinants of health among children enrolled in the Kids-duration of therapy for thrombosis trial. Methods: We conducted a secondary analysis of the multinational Kids-duration of therapy for thrombosis parallel-cohort randomized controlled trial (NCT00687882). We limited our analysis to United States participants and utilized the 8 Health Resources and Services Administration-designated geographic regions to construct 4 consolidated regions. After exclusions, 409 participants were evaluable. Results: The location of VTE varied by age ( Conclusion: These findings suggest the need for further studies to determine optimal posttreatment follow-up in this older age group to increase PTS detection rates. We recommend that future collaborative pediatric VTE studies systematically collect social determinants of health variables to better assess their impact on VTE presentation, treatment, and outcomes in children.

Indexed as

Postthrombotic SyndromeVenous ThromboembolismVenous ThrombosisAdolescentAge FactorsChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleRecurrenceRisk FactorsSocial Determinants of HealthSociodemographic Factorschildsocial determinants of healththrombosisvenous insufficiencyvenous thromboembolism

Identifiers

PMID42657323
PMCPMC13508622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.