Evidence map›Paper›PMID 42657286›Full record

ArticleChemical & biomedical imaging2026

A pH/ATP Dual-Sensitive Nanoprobe-Based Bioluminescence Imaging for Intraoperative Human Multicancer Detection.

Xiaofeng He, Jiahui Wang, Junwei Li, Yangsi Zheng, Wenqi Shi, Jiatian Song, Jiayu Li, Zhiyong Wu, Menglong Zhao, Tiantian Zhai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaofeng HeDepartment of Radiotherapy, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.ORCID https://orcid.org/0000-0001-8936-2945
Jiahui WangClinical Research Center, Shantou Central Hospital, Shantou 515031, China.
Junwei LiClinical Research Center, Shantou Central Hospital, Shantou 515031, China.
Yangsi ZhengDepartment of Biobank, Shantou Central Hospital, Shantou 515031, China.
Wenqi ShiDepartment of Plastic Surgery and Burns Center, Second Affiliated Hospital of Shantou University Medical College, Shantou 515031, China.
Jiatian SongDepartment of Radiotherapy, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
Jiayu LiDepartment of Radiotherapy, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
Zhiyong WuDiagnosis and Treatment Center of Breast Diseases, Shantou Central Hospital, Shantou 515031, China.
Menglong ZhaoClinical Research Center, Shantou Central Hospital, Shantou 515031, China.
Tiantian ZhaiDepartment of Radiotherapy, Cancer Hospital of Shantou University Medical College, Shantou 515031, China.
Siqi QiuDiagnosis and Treatment Center of Breast Diseases, Shantou Central Hospital, Shantou 515031, China.ORCID https://orcid.org/0000-0002-8870-0639

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current intraoperative cancer diagnosis predominantly relies on frozen section histopathology, which is time-consuming and prone to sampling bias. Development of techniques for intraoperative cancer diagnosis is urgently needed. Notably, malignant tumors manifest distinctive microenvironmental signatures characterized by acidic pH gradients and elevated ATP concentrations, which are important biomarkers for tumor identification. Based on these signatures, a pH/ATP dual-sensitive bioluminescent nanoprobe, d-luciferase-liposome-PEOz (DLPNPs), was engineered using thin-film hydration. The nanoprobe displayed a spherical morphology (∼140 nm in diameter), low pH-dependent activation (pH <6.5), and good biocompatibility

Indexed as

ATP-sensitive nanoprobebioluminescence imagingintraoperative cancer diagnosismulticancerpH-sensitive nanoprobe

Identifiers

PMID42657286
PMCPMC13508473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.