TyrRu: A Tyramide-Amplified Multimodal Ruthenium Tag for Elemental Mass Spectrometry and Immunofluorescence Imaging.

Rosemary J Bergin, Ioannis Kohilas, Thomas E Lockwood, Andrew M McDonagh, Mika T Westerhausen, David P Bishop

Abstract read

In one paragraph

Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Rosemary J BerginSchool of Mathematical and Physical Sciences, The University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID https://orcid.org/0000-0003-0868-1800

Ioannis KohilasSchool of Mathematical and Physical Sciences, The University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID https://orcid.org/0009-0009-6450-1131

Thomas E LockwoodSchool of Mathematical and Physical Sciences, The University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID https://orcid.org/0000-0001-7030-1341

Andrew M McDonaghSchool of Mathematical and Physical Sciences, The University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID https://orcid.org/0000-0002-9502-1175

Mika T WesterhausenSchool of Mathematical and Physical Sciences, The University of Technology Sydney, Sydney, NSW 2007, Australia.

David P BishopSchool of Mathematical and Physical Sciences, The University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID https://orcid.org/0000-0002-6533-4410

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tyramide signal amplification, used in immunohistochemistry to image low-abundance biomolecules, has seen adaptation beyond conventional microscopy and is utilized in flow cytometry and electron microscopy. Here, we applied tyramide signal amplification to image biomolecules via elemental mass spectrometry imaging (MSI). Elemental MSI techniques such as laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) are used to image biomolecules via metal-conjugated probes, and resolution is typically hampered by a low detection sensitivity. We report the synthesis of a bespoke ruthenium complex (

Indexed as

immunofluorescenceLA-ICP-MSmultimodal imagingsubcellular imagingtyramide signal amplificationTyrRu

Identifiers

PMID42657241

DOI10.1021/cbmi.6c00007

PMCPMC13508111

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.