ReviewFood science & nutrition2026
Fatty Acid Signatures as Nutritional Indices: Molecular Gateways to Health, Aging, and Functional Food Innovation.
Review in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acid signatures (FA signatures), defined as the relative distribution of saturated, monounsaturated, and polyunsaturated fatty acids within specific biological compartments, have emerged as integrated indicators of dietary lipid exposure, endogenous metabolism, and tissue-specific lipid remodeling. Rather than serving solely as biomarkers of nutritional intake, FA signatures influence membrane architecture, cellular signaling, inflammatory regulation, mitochondrial function, and gene expression, linking dietary lipid quality with metabolic health, chronic disease susceptibility, and biological aging. This review critically synthesized current evidence on the biosynthesis, regulation, analytical assessment, and biological significance of FA signatures, with particular emphasis on cardiometabolic health, neuroinflammation, cognitive aging, and healthy longevity. We distinguish the complementary roles of conventional fatty acid profiling and high-resolution lipidomics in resolving fatty acid composition and molecular lipid species, while highlighting persistent analytical challenges, including biological matrix specificity and the limited resolution of positional and geometric fatty acid isomers. We further examine how integration of lipidomics with nutrigenomics, metabolomics, foodomics, and emerging computational approaches can improve mechanistic interpretation, biomarker discovery, and precision nutrition. Collectively, FA signatures represent dynamic metabolic phenotypes that connect dietary exposure with membrane biology, metabolic regulation, and healthy aging, while providing a promising foundation for evidence-based nutritional strategies and next-generation functional food research.
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