ArticleChemical & biomedical imaging2026
Site-Specific Labeling of PD-L1 Fab through Disulfide Rebridging for ImmunoPET Imaging.
Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immuno-positron emission tomography is a powerful tool for noninvasive in vivo visualization of antibody distribution and binding in tissues or organs. However, the current chemical toolbox for generating immunoPET probes compromises key attributes such as homogeneity, structural integrity, and batch-to-batch reproducibility. Quinoxaline bis-nitriles have been reported to site-selectively label antibodies via disulfide bond rebridging with robust efficiency and stability. In this study, we applied this approach to establish this chemistry for rapidly generating structurally defined Fab-based probes for in vivo imaging. Initially, we employed a NODAGA-functionalized bis-nitrile derivative to generate a PD-L1 PET probe for in vivo PET imaging with
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