Evidence map›Paper›PMID 42657128›Full record

ArticleInternational journal of hepatology2026

Incident Cognitive Impairment in Nonobese Versus Obese Adults Aged 50 Years or Older With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Propensity Score-Matched Cohort Study.

Akram Alnounou, Mohammad Alabbas, Riddhi Machchhar, EzzEIDien A Ibrahim, Mohammad Alali, Ahmad Alhusen, Syed-Mohammed Jafri, Basile Njei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akram AlnounouDepartment of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA, wmich.edu.ORCID https://orcid.org/0009-0002-5657-1139
Mohammad AlabbasDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, Ohio, USA, clevelandclinic.org.ORCID https://orcid.org/0000-0001-7981-2682
Riddhi MachchharDepartment of Medicine, Saint Peter's University Hospital/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA, duhs.edu.pk.ORCID https://orcid.org/0000-0002-8744-707X
EzzEIDien A IbrahimDepartment of Internal Medicine, University of Missouri-Columbia, Columbia, Missouri, USA, missouri.edu.ORCID https://orcid.org/0000-0002-9403-5970
Mohammad AlaliDepartment of Internal Medicine, Henry Ford Macomb Hospital, Clinton Township, Michigan, USA, henryford.com.ORCID https://orcid.org/0009-0009-1646-5375
Ahmad AlhusenDepartment of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA, advocatehealth.com.ORCID https://orcid.org/0009-0007-2435-8743
Syed-Mohammed JafriDepartment of Gastroenterology and Hepatology, Henry Ford Health System, Detroit, Michigan, USA, henryford.com.ORCID https://orcid.org/0000-0001-8108-7408
Basile NjeiSection of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA, yale.edu.ORCID https://orcid.org/0000-0003-0714-4368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Nonobese metabolic dysfunction-associated steatotic liver disease (MASLD) may carry disproportionate neurodegenerative risk, but whether body habitus modifies cognitive risk within MASLD remains unresolved. We compared cognitive impairment between nonobese and obese adults aged 50 years or older with MASLD. Methods and Results: Retrospective cohort study with 1:1 propensity score matching in the TriNetX Research Network, a federated electronic health record network. Adults with a first MASLD diagnosis (2016-2022) meeting a metabolic-risk criterion were classified by index body mass index as nonobese (18.50-29.99 kg/m Conclusion: Among adults aged 50 years or older with MASLD, nonobese status was associated with a modestly higher risk of incident cognitive impairment. Prospective validation in imaging- or biomarker-confirmed MASLD cohorts is warranted.

Indexed as

body mass indexcognitive dysfunctioncohort studiesdementiametabolic dysfunction-associated steatotic liver disease (MASLD)

Identifiers

PMID42657128
PMCPMC13509417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.