Evidence map›Paper›PMID 42657082›Full record

ArticleJournal of translational internal medicine2026

Circulating serum 25-hydroxyvitamin D levels and bone mineral density and osteoporotic vertebral fractures: A Mendelian randomization study.

Lihui Chen, Jiao Zhao, Zhenlin Zhang, Chao Gao

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Article in Journal of translational internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Lihui ChenDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiao ZhaoDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhenlin ZhangDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-4339-1617
Chao GaoDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0009-0009-7733-7983

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Low serum 25-hydroxyvitamin D (25OHD) has been associated with osteoporosis and osteoporotic fracture, but whether these associations are causal remains unclear. Methods: We identified 15 single-nucleotide polymorphisms (SNPs) affecting serum 25OHD levels in seven genes in the peripheral blood genomic deoxyribonucleic acid (DNA) of 2061 community-based people aged 20-92 years (711 men and 1350 women) and 200 outpatients aged 55-85 years with vertebral fractures (36 men and 164 women). Our study employs Mendelian randomization (MR) to determine the causal relationship between serum 25OHD concentration and bone mineral density (BMD), bone turnover markers (BTMs), and vertebral fracture. Results: MR analysis indicated no correlation between hereditary 25OHD levels and BMD, procollagen type 1 N-terminal propeptide (P1NP), carboxy-terminal telopeptide of type 1 collagen (CTX), and vertebral fractures (all Conclusions: Our findings suggest that baseline 25OHD levels are unlikely to have a large effect on risk of vertebral fractures. Larger MR studies and randomized controlled trials are required to investigate small effects.

Indexed as

25-hydroxyvitamin Dbone mineral densitymendelian randomizationsingle nucleotide polymorphismsvertebral fractures

Identifiers

PMID42657082
PMCPMC13509146

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.