ReviewHealth science reports2026
Global Burden of Meconium-Stained Amniotic Fluid: A Systematic Review and Meta-Analysis of Prevalence With Descriptive Synthesis of Determinants.
Review in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Meconium-stained amniotic fluid (MSAF) is a common intrapartum finding associated with adverse perinatal outcomes. Comprehensive global estimates of its prevalence and determinants are lacking. This systematic review and meta-analysis aimed to estimate the global pooled prevalence of MSAF and classify its associated factors. Methods: We searched Ovid MEDLINE, Scopus, Web of Science, Embase, Cochrane Library, SID, and Google Scholar up to January 1, 2026, for observational studies reporting MSAF prevalence or associated factors. Pooled prevalence with 95% CI was calculated using a random-effects model with Logit transformation. The Knapp-Hartung adjustment and 95% prediction interval were applied. Heterogeneity was quantified using Results: Fifty-one studies were included (44 for prevalence; 1,414,705 births). The global pooled prevalence was 13.0% (95% CI: 10.8-15.6%; prediction interval: 6.9-23.1%; Conclusion: MSAF affects one in eight pregnancies globally, with a higher burden in low-income settings. Four-domain classification identifies actionable targets-intrapartum monitoring failures and health-system barriers-for quality improvement. Meconium consistency grading offers a simple risk stratification tool. Addressing these factors, particularly in resource-limited settings, can reduce preventable perinatal morbidity and align with global health equity goals.
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