Single- Versus Multi-Fraction Stereotactic Body Radiotherapy for Primary Lung Cancer and Pulmonary Oligometastases: A Systematic Review and Meta-Analyses.

Ishaan Pillay, Harriet Gee, Eric Hau, Anselm Ong, Val Gebski

Abstract readReview

In one paragraph

Review in JTO clinical and research reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ishaan PillayRadiation Oncology Network, Western Sydney Local Health District, Sydney, New South Wales, Australia.

Harriet GeeRadiation Oncology Network, Western Sydney Local Health District, Sydney, New South Wales, Australia.

Eric HauRadiation Oncology Network, Western Sydney Local Health District, Sydney, New South Wales, Australia.

Anselm OngRadiation Oncology Network, Western Sydney Local Health District, Sydney, New South Wales, Australia.

Val GebskiRadiation Oncology Network, Western Sydney Local Health District, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic body radiation therapy (SBRT), the standard of care for medically inoperable early-stage NSCLC, is increasingly used for pulmonary oligometastases. Optimal fractionation-single fraction (SF) versus multiple fractions (MF)-remains unclear, as existing randomized studies lack power to confirm SF noninferiority in local control. This review assessed 2-year local failure (LF) rates for SF versus MF SBRT. PubMed, Ovid Medline, and the Cochrane Library were searched. Titles and abstracts were reviewed followed by full-text review. Studies reporting LF outcomes for SF or MF SBRT in early-stage NSCLC or pulmonary metastases were included. Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Cochrane Handbook for Systematic Reviews guidelines were followed. Pooled estimates were calculated using fixed- and random-effects models. Primary lung cancers treated with biologically effective doses (BED

Indexed as

Multi-fractionPrimary lung cancerPulmonary oligometastasesSingle fractionStereotactic ablative body radiotherapy

Identifiers

PMID42657018

DOI10.1016/j.jtocrr.2026.101005

PMCPMC13508619

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.