Evidence map›Paper›PMID 42656962›Full record

ArticlePrecision chemistry2026

Solvent-Directed Phase Control in Disulfide-Linked Metal-Organic Frameworks Revealed by Microcrystal Electron Diffraction.

Patrick F Strobel, Lucas Laventure, Priyanshu Chandra, Mark Del Campo, Pierre LeMagueres, Lauren Aheran, Jing Jin, Nathan J Oldenhuis, David Punihaole, Aylin Aykanat

Abstract read
In one paragraph

Article in Precision chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patrick F StrobelDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, New Hampshire 03824, United States.ORCID https://orcid.org/0009-0006-9100-2715
Lucas LaventureDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, New Hampshire 03824, United States.
Priyanshu ChandraDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, New Hampshire 03824, United States.ORCID https://orcid.org/0000-0002-5881-8679
Mark Del CampoRigaku Americas Corporation, 9009 New Trails Dr., The Woodlands, Texas 77381, United States.ORCID https://orcid.org/0009-0003-0819-2481
Pierre LeMagueresRigaku Americas Corporation, 9009 New Trails Dr., The Woodlands, Texas 77381, United States.
Lauren AheranDepartment of Chemistry, College of Arts and Sciences, University of Vermont, 82 University Pl, Innovation Hall, Burlington, Vermont 05405, United States.
Jing JinMaterials Characterization Center, Boston College, 245 Beacon Street, Chestnut Hill, Massachusetts 02467, United States.ORCID https://orcid.org/0000-0002-1847-7136
Nathan J OldenhuisDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, New Hampshire 03824, United States.ORCID https://orcid.org/0000-0003-4256-0826
David PunihaoleDepartment of Chemistry, College of Arts and Sciences, University of Vermont, 82 University Pl, Innovation Hall, Burlington, Vermont 05405, United States.ORCID https://orcid.org/0000-0002-4637-9672
Aylin AykanatDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, New Hampshire 03824, United States.ORCID https://orcid.org/0000-0002-1721-772X

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI DON Michael WOJCHOWSKI · 2017 to 2026
$22.8M
NIGMS NIH HHS P20 GM113131
6 · The paper itself

Abstract

Precise control over phase, topology, and reactivity in metal-organic frameworks (MOFs) is critical for translating chemical responsiveness into predictable function. Disulfide-linked coordination networks are attractive flexible materials, yet their strong sensitivity to synthesis conditions has hindered mechanistic understanding of how the structure governs reactivity. Here, we achieve phase control in a zinc disulfide MOF system by tuning solvent coordination and water activity, enabling access to a microcrystalline open-pore structure (Zn-MOF-α) and a dense, topologically distinct isomer (Zn-MOF-β) from the same disulfide linker. Microcrystal electron diffraction (MicroED) studies determined both structures directly from micro- and nanocrystalline particles, revealing distinct secondary building units (SBUs), connectivity, and pore architecture. Systematic solvent studies identify water as a driver of α → β transformation, while the reverse transformation (β → α) is accessible in solutions of

Indexed as

disulfideelectron paramagnetic resonance (EPR)metal−organic frameworks (MOFs)mirco-electron diffraction (MicroED)phase selectionpowder X-ray diffraction (PXRD)reversible isomerization

Identifiers

PMID42656962
PMCPMC13508512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.