Evidence map›Paper›PMID 42656944›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Decreased cerebral metabolic rate of oxygen (CMRO

Hangwei Zhuang, Liangdong Zhou, Xiuyuan Hugh Wang, Emily B Tanzi, Yi Li, Pascal Spincemaille, Ilhami Kovanlikaya, Thanh D Nguyen, Yi Wang, Gloria C Chiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Decreased cerebral metabolic rate of oxygen (CMROAlzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hangwei ZhuangDepartment of Radiology, MRI Research Institute Weill Cornell Medicine New York New York USA.ORCID https://orcid.org/0000-0001-7662-1434
Liangdong ZhouDepartment of Radiology, Brain Health Imaging Institute Weill Cornell Medicine New York New York USA.
Xiuyuan Hugh WangDepartment of Radiology, Brain Health Imaging Institute Weill Cornell Medicine New York New York USA.
Emily B TanziDepartment of Radiology, Brain Health Imaging Institute Weill Cornell Medicine New York New York USA.
Yi LiDepartment of Radiology, Brain Health Imaging Institute Weill Cornell Medicine New York New York USA.
Pascal SpincemailleDepartment of Radiology, MRI Research Institute Weill Cornell Medicine New York New York USA.
Ilhami KovanlikayaDepartment of Radiology, MRI Research Institute Weill Cornell Medicine New York New York USA.
Thanh D NguyenDepartment of Radiology, MRI Research Institute Weill Cornell Medicine New York New York USA.
Yi WangDepartment of Radiology, MRI Research Institute Weill Cornell Medicine New York New York USA.
Gloria C ChiangDepartment of Radiology, Brain Health Imaging Institute Weill Cornell Medicine New York New York USA.ORCID https://orcid.org/0000-0001-9925-0816

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Noninvasive measurement of oxygenation using quantitative susceptibility mapping (supplement)R01HL151686 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SPINCEMAILLE, PASCAL, WEINSAFT, JONATHAN W. · 2021 to 2025
$4.7M
CSF Clearance in Sporadic Alzheimer's DiseaseR01AG057848 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI LI, YI · 2018 to 2023
$4.0M
Quantitative MRI-based cerebral oxygen metabolism in Alzheimer's diseaseR01AG080011 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLORIA Chia-Yi CHIANG, Yi Wang · 2023 to 2026
$3.3M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NHLBI NIH HHS R01 HL151686NIA NIH HHS R01 AG057848NIA NIH HHS R01 AG080011
6 · The paper itself

Abstract

Introduction: Transgenic Alzheimer's (AD) mouse models and Methods: We assessed tau using Results: Across all subjects, higher tau standardized uptake value ratio (SUVR) was associated with lower cerebral blood flow (CBF) and CMRO Discussion: MRI-derived CBF and CMRO

Indexed as

Alzheimer's diseasecerebral blood flow (CBF)cerebral metabolic rate of oxygen (CMRO2)magnetic resonance imaging (MRI)oxygen extraction fraction (OEF)tau PET

Identifiers

PMID42656944
PMCPMC13508576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.