Evidence map›Paper›PMID 42656915›Full record

ArticleMedComm2026

Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta-Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence.

Yujin Shi, Bin Huang, Xiaohong Liu, Yalan Liu, Qinyong Hu, Tianyu Lei, Luqi Tang, Guanglin Xiao, Tingting Ning, Shengqin Yue and 8 more

Abstract read
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yujin ShiDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.
Bin HuangDepartment of Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing China.
Xiaohong LiuDepartment of Oncology Renmin Hospital of Wuhan University Wuhan China.
Yalan LiuDepartment of Pediatric Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Qinyong HuDepartment of Oncology Renmin Hospital of Wuhan University Wuhan China.
Tianyu LeiDepartment of Oncology Renmin Hospital of Wuhan University Wuhan China.
Luqi TangDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.
Guanglin XiaoDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.
Tingting NingDepartment of Oncology Renmin Hospital of Wuhan University Wuhan China.
Shengqin YueDepartment of Oncology Renmin Hospital of Wuhan University Wuhan China.
Jiahui HeDepartment of Oncology Renmin Hospital of Wuhan University Wuhan China.ORCID https://orcid.org/0009-0004-4395-504X
Qilian DuDepartment of Oncology Renmin Hospital of Wuhan University Wuhan China.
Xuanmei LiDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.
Yixuan ZhouDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.
Qiongfang ZhangDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.
Chunyan QiDepartment of Cardiology The Second Affiliated Hospital of Chongqing Medical University Chongqing China.ORCID https://orcid.org/0000-0002-9420-9635
Hong RenDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.
Hong-Gang RenDepartment of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University Chongqing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Associations between various genetic variants and the risk of hepatocellular carcinoma (HCC) have been extensively explored but produced contradictory results. The aim of the present systematic meta-analysis was to determine and validate genetic variants that are associated with HCC risk. Two-step literature searches of PubMed, Embase, Web of Science, and Google Scholar databases and various meta-analyses were performed, and a comprehensive field synopsis and epidemiological evidence were provided. A total of 20,081 publications were identified, of which 830 were deemed eligible for inclusion. Eventually, 36 variants in 27 genes were identified to be associated with HCC risk. Moreover, cumulative epidemiological evidence of an association was graded as moderate for nine variants in eight genes (

Indexed as

genetichepatocellular carcinomameta‐analysispolymorphismvariant

Identifiers

PMID42656915
PMCPMC13507827

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.