Evidence map›Paper›PMID 42656910›Full record

ArticleJACS Au2026

The FAD-Dependent Monooxygenase Albo65 Mediates Self-Resistance in Albofungin Biosynthesis.

Zehui Liu, Chunshuai Huang, Hao Xu, Lingyang Zhu, Huimin Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zehui LiuDepartment of Chemistry, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID https://orcid.org/0000-0001-6265-4139
Chunshuai HuangCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID https://orcid.org/0000-0002-3126-2340
Hao XuDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.
Lingyang ZhuSchool of Chemical Sciences NMR Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID https://orcid.org/0000-0002-6657-271X
Huimin ZhaoDepartment of Chemistry, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID https://orcid.org/0000-0002-9069-6739

Funding

A Scalable Platform to Discover Antimicrobials of Ribosomal OriginR01AI144967 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Douglas Alan Mitchell, WILFRED A. VAN DER DONK · 2019 to 2026
$6.0M
Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
NIAID NIH HHS R01 AI144967NIGMS NIH HHS T32 GM070421
6 · The paper itself

Abstract

The production of specialized small molecules in microorganisms often involves self-resistance mechanisms to prevent autotoxicity. Albofungins belong to the xanthone-containing aromatic polyketides with potent antimicrobial activities. However, its self-resistance mechanism remains unknown. Here we report the discovery of a flavin adenine dinucleotide (FAD)-dependent monooxygenase, Albo65, that mediates self-resistance in albofungin biosynthesis in

Indexed as

antibiotic resistancenatural product biosynthesisoxidative inactivationsynthetic biologyxanthone polyketideyeast selection marker

Identifiers

PMID42656910
PMCPMC13508088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.