Strontium-incorporated thermoresponsive hydrogel platform co-delivering graphene oxide-mannose nanocomplexes: An osteoimmunomodulatory strategy for periodontitis therapy.

Linxin Chen, Jiayi Cai, Lin Liu, Geyuan Zheng, Sihang Chen, Maotuan Huang, Linyu Xu, Wenxiu Yuan

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Linxin ChenClinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Jiayi CaiClinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Lin LiuClinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Geyuan ZhengClinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Sihang ChenClinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Maotuan HuangDepartment of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital Fujian Medical University, Fuzhou, 350000, China.

Linyu XuClinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Wenxiu YuanClinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is an immune-mediated disease that destroys tooth-supporting tissues, yet existing treatments cannot synchronize inflammation resolution with bone regeneration. To address this unmet need, we report an injectable, strontium-incorporated an injectable thermoresponsive hydrogel (composed of chitosan, 0.6% gelatin, and β-glycerophosphate) platform engineered for the delivery of graphene oxide-mannose nanocomplexes (designated GM-Sr@Hydrogel). Upon injection, this platform undergoes rapid thermoresponsive stiffening, enabling the localized and controlled release of Sr

Indexed as

Graphene oxideMannoseOsteoimmunomodulationPeriodontitisStrontiumThermosensitive hydrogel

Identifiers

PMID42656903

DOI10.1016/j.mtbio.2026.103566

PMCPMC13507548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.