ArticleChemical & biomedical imaging2026
Preliminary Application of TROP2-Targeted Peptide Screening for Real-Time Intraoperative Navigation in Pancreatic Cancer.
Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fluorescence-guided surgery (FGS) in the near-infrared II (NIR-II) window offers improved tissue penetration and higher signal-to-background ratios, but widely used nonspecific probes such as indocyanine green (ICG) lack tumor selectivity, limiting their value in pancreatic ductal adenocarcinoma (PDAC). Here, we identified trophoblast cell surface antigen 2 (TROP2) as an imaging target and developed a TROP2-targeted peptide-based NIR-II probe, HCP-ICG, for precision intraoperative navigation. The high-affinity TROP2-binding peptide HCP (HYEYWDEEHEC) was discovered through an OBOC peptide library and conjugated to ICG to yield HCP-ICG. The probe exhibited nanomolar affinity (KD = 2.64 × 10
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