Evidence map›Paper›PMID 42656857›Full record

ReviewJPGN reports2026

Shaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from a SIGENP expert groups.

Carlo Agostoni, Daniele Alberti, Renata Auricchio, Maria Elisabetta Baldassarre, Osvaldo Borrelli, Matteo Bramuzzo, Teresa Capriati, Carlo Catassi, Sabrina Cenni, Marco Crocco and 37 more

Abstract readReview
In one paragraph

Review in JPGN reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Carlo AgostoniFondazione De Marchi - Pediatric Area, IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy.
Daniele AlbertiDepartment of Pediatric Surgery, ASST Spedali Civili Children Hospital University of Brescia Brescia Italy.
Renata AuricchioDepartment of Translational Medicine & European Laboratory for the Investigation of Food-Induced Diseases University Federico II Naples Italy.
Maria Elisabetta BaldassarreDepartment of Interdisciplinary Medicine- Neonatology and NICU Section University "Aldo Moro" of Bari Bari Italy.
Osvaldo BorrelliDepartment of Paediatric Gastroenterology Great Ormond Street Hospital for Children London UK.
Matteo BramuzzoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo" Trieste Italy.
Teresa CapriatiDigestive Diseases and Rehabilitation Clinical Unit; Nutritional Treatments of Complex Disease Research, Unit of Pediatric, Hospital Bambino Gesù Rome Italy.
Carlo CatassiDepartment of Pediatrics Polytechnic University of Marche Ancona Italy.
Sabrina CenniPediatric Emergency Unit, Santobono-Pausilipon Children's Hospital, AORN Naples Italy.
Marco CroccoPediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini Genova Italy.
Salvatore CucchiaraSapienza Università di Roma Roma Italy.
Luigi Dall'OglioBambino Gesù Children's Hospital Rome Italy.
Paola De AngelisDigestive Endoscopy and Surgery Unit Bambino Gesù Children's Hospital Rome Italy.
Marco Deganello SaccomaniDepartment of Paediatrics Woman's & Child's University Hospital of Verona Verona Italy.
Fabiola Di DatoDipartimento di Scienze Mediche Traslazionali Sezione di Pediatria Università degli Studi di Napoli Federico II Naples Italy.
Angelo Di GiorgioDepartment of Medicine University of Udine Udine Italy.
Antonella DiamantiDigestive Diseases and Rehabilitation Clinical Unit; Nutritional Treatments of Complex Disease Research Unit of Pediatric Hospital Bambino Gesù Rome Italy.
Valeria DipasqualeDepartment of Human Pathology in Adulthood and Childhood "G. Barresi", Pediatric Gastroenterology and Cystic Fibrosis Unit University of Messina Messina Italy.
Enrico FeliciPediatric and Pediatric Emergency Unit, Children's Hospital, AOU SS Antonio E Biagio E C. Arrigo Alessandria Italy.
Ruggiero FrancavillaPediatric Gastroenterology and Hepatology Unit, Department of Interdisciplinary Medicine, Children's Hospital-Giovanni XXIII University of Bari Aldo Moro Bari Italy.
Valentina GiorgioDepartment of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS Università Cattolica del Sacro Cuore Rome Italy.
Luigi GrecoEuropean Laboratory for Food-Induced Disease University of Naples Federico II Naples Italy.
Raffaele LorioDipartimento di Scienze Mediche Traslazionali Epatologia Pediatrica Università di Napoli Federico II Naples Italy.
Flavio LabriolaPediatric Gastroenterology Unit, Maggiore Hospital Bologna Italy.
Paolo LionettiDepartment Neurofarba University of Florence, Meyer Children's Hospital IRCCS Florence Italy.
Elena LionettiDepartment of Pediatrics Marche Polytechnic University Ancona Italy.
Giuseppe MaggioreDivision of Hepatogastroenterology and Liver Transplant, ERN RARE LIVER, Bambino Gesù Children's Hospital, IRCCS Rome Italy.
Monica MalamisuraGastroenterology and Nutrition Unit, Bambino Gesù Children's Hospital, IRCCS Rome Italy.
Claudia MandatoDipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Section of Pediatrics Baronissi (Salerno) Italy.
Antonio MarsegliaFondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo (Fg) Italy.
Emanuele NicastroHepatology, Gastroenterology and Transplantation Unit, Hospital Papa Giovanni XXIII Bergamo Italy.
Lorenzo NorsaDepartment of Pediatrics, Vittore Buzzi Children's Hospital University of Milan Milan Italy.
Salvatore OlivaPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department Sapienza - University of Rome Rome Italy.
Licia PensabenePediatric Unit, Department of Medical and Surgical Sciences University "Magna Graecia" of Catanzaro Catanzaro Italy.
Elena Sofia PieriPediatric Unit, San Donato Hospital Arezzo Italy.
Paolo QuitadamoDepartment of Pediatrics Santobono-Pausilipon Children's Hospital Naples Italy.
Giusy RanucciDepartment of Pediatrics, Liver Transplant Center UPMC-ISMETT Palermo Palermo Italy.
Sara RenzoGastroenterology and Nutrition Unit, Meyer Children's Hospital Florence Italy.
Claudio RomanoDepartment of Human Pathology in Adulthood and Childhood "G. Barresi" Pediatric, Gastroenterology and Cystic Fibrosis Unit University of Messina Messina Italy.ORCID https://orcid.org/0000-0001-8827-2091
Silvia SalvatorePediatric Unit, Hospital "F. Del Ponte", Department of Medicine and Technical Innovation University of Insubria Varese Italy.
Luca ScaralloGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS Florence Italy.
Maria Immacolata SpagnuoloDepartment of Translational Medical Sciences University "Federico II" of Naples Naples Italy.
Annamaria StaianoDepartment of Translational Medical Sciences-Section of Pediatric University Federico II Naples Italy.
Caterina StrisciuglioDepartment of Woman, Child and General and Specialistic Surgery University of Campania "Luigi Vanvitelli" Napoli Italy.
Renato TambucciGastroenterology and Nutrition Unit, Bambino Gesù Children's Hospital IRCCS Rome Italy.
Riccardo TronconeDepartment of Medical Translational Sciences and European Laboratory for the Investigation of Food-Induced Diseases University Federico II Naples Italy.
Pietro VajroDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno Salerno Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) recognized the need to define research priorities and identify knowledge gaps to guide future investigations in pediatric digestive health. Following international examples, SIGENP aimed to provide a structured framework that aligns scientific innovation with clinical relevance and patient-centered outcomes. This narrative review represents the consensus output of SIGENP's thematic working groups (WGs) in key fields-inflammatory bowel disease (IBD), Gastrointestinal Endoscopy, Hepatology, Nutrition and Intestinal Failure, Functional and Motility Disorders, and Allergy and Immunity. Each WG conducted a focused review of recent literature, national activities, and registry data, identifying unmet needs and defining strategic objectives. Draft reports were refined through plenary discussions and finalized by consensus during dedicated SIGENP meetings. Across all areas, shared priorities emerged: advancing precision and personalized medicine, integrating multi-omics and digital tools, and promoting pediatric-specific evidence through multicenter collaboration and harmonized registries. Disease-specific gaps include early diagnosis and biomarker discovery in IBD and liver disease, standardization of pediatric endoscopy and motility diagnostics, optimization of nutritional interventions and intestinal failure management, and the exploration of organoid and immune models in celiac disease and food allergy. This review outlines a comprehensive research agenda in pediatric gastroenterology, hepatology, and nutrition developed through a structured SIGENP expert process. It provides a strategic framework to guide future research initiatives, foster collaboration, and ultimately improve outcomes for children with gastrointestinal and nutritional disorders.

Indexed as

multicenter collaborationpediatric gastroenterology researchprecision medicinereal‐world evidencetranslational science

Identifiers

PMID42656857
PMCPMC13507637

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.