Association of early oxygen therapy parameters with retinopathy of prematurity stages in preterm infants with respiratory distress syndrome: a gestational age-stratified analysis.

Shanshan Chen, Rong Li, Na Shi, Qinxing Xie, Wenqiang Liu

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Shanshan ChenDepartment of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Rong LiDepartment of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Na ShiDepartment of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Qinxing XieDepartment of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Wenqiang LiuDepartment of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Funding

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6 · The paper itself

Abstract

Objective: To investigate the associations between early oxygen-related parameters and ROP severity in preterm infants with respiratory distress syndrome (RDS), and to evaluate their discriminative performance for severe ROP. Methods: This retrospective study included 825 preterm infants (24-<37 weeks) with RDS stratified by gestational age (32-<37, 28-<32, and 24-<28 weeks). Early oxygen parameters during the first 7 days after birth included cumulative oxygen duration, mean and maximum FiO Results: ROP incidence was 12.97% (107/825) and increased with decreasing gestational age (1.21%, 25.80%, and 59.57%, respectively; Conclusion: Early oxygen-related parameters were associated with ROP severity but showed limited independent discriminative value beyond gestational age and birth weight. They may represent candidate markers for risk characterization, although prospective validation is required before clinical application.

Indexed as

early oxygen therapy parametersgestational age stratificationpreterm infantrespiratory distress syndromeretinopathy of prematurity stage

Identifiers

PMID42656831

DOI10.3389/fped.2026.1911394

PMCPMC13506896

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