Evidence map›Paper›PMID 42656826›Full record

ArticleJACS Au2026

Carbon Dots as Electrostatically Driven Base-Selective Chemical Compilers for Programmable Nucleic Acid Condensation.

Chengyi Hu, Dongdong He, Zitong Niu, Yu Li, Junjie Fan, Kejian Ding, Yuan Li, Pan Fu, Sihua Qian, Jiang Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chengyi HuNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.
Dongdong HeNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.
Zitong NiuNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.
Yu LiDepartment of Nanomedicine, Naval Medical University, Shanghai 200433, China.
Junjie FanNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.
Kejian DingNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.
Yuan LiNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.
Pan FuNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.ORCID https://orcid.org/0000-0002-6438-669X
Sihua QianNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.ORCID https://orcid.org/0000-0003-4023-9545
Jiang LiInstitute of Materiobiology, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China.ORCID https://orcid.org/0000-0003-2372-6624
Yuhui WangNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.ORCID https://orcid.org/0000-0001-9430-6614
Limin ZhouShanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China.
Kaizhe WangNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300, China.ORCID https://orcid.org/0000-0003-0331-6847

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells execute complex biological functions through programmed biomolecular condensation, yet a general and programmable strategy for nucleic acid condensation in vitro remains challenging. Here, we demonstrate that carbon dots (CDs) function as an electrostatic-driven versatile chemical compiler that translates nucleobase sequence into programmed condensate architectures and functions. We found that citric acid-ethylene diamine carbon dots (CA-EDA CDs) drive the condensation of both ssDNA and mRNA via multiple weak interactions. Crucially, the spatially heterogeneous electrostatic potential on the CD surface decodes the distinct electrostatic properties of nucleobases through Coulomb-dominated interactions, establishing a definitive binding hierarchy (G > C >

Indexed as

Artificial cellBiomimetic cellsCarbon dotsDNA nanomaterialsNucleic acid condensates

Identifiers

PMID42656826
PMCPMC13508071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.