ArticleFrontiers in aging neuroscience2026
Impact of ultrasound-guided nerve block on postoperative delirium in elderly patients undergoing diabetic foot surgery: a propensity score-matched retrospective study.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Postoperative delirium (POD) is a common and serious complication in elderly patients undergoing diabetic foot surgery, often linked to excessive opioid use and systemic neuroinflammation. This study aimed to evaluate whether ultrasound-guided nerve block (NB) reduces the incidence of POD compared to general anesthesia (GA) in this high-risk population. Methods: We conducted a propensity score-matched (PSM) retrospective cohort study involving 137 patients. The primary outcome was the incidence of POD, while secondary outcomes included intraoperative opioid consumption (sufentanil equivalent) and postoperative interleukin-6 (IL-6) levels. Standardized mean differences (SMDs) were used to assess covariate balance after matching. Results: After PSM, the incidence of POD was significantly lower in the NB group (5.6%) than in the GA group (25.0%, Conclusion: Ultrasound-guided NB is associated with a lower POD risk in elderly patients with diabetic foot, consistent with potential mediation through opioid-sparing and anti-inflammatory mechanisms.
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