SynthesisFrontiers in public health2026
Exit-site infection and subsequent incident risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study with meta-analysis.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Global, Regional, and Country Incidence of Peritoneal Dialysis-Associated Peritonitis in the Contemporary Peritoneal Dialysis Practice: A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2026Pooled it
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To date, evidence to support the risk estimates of peritoneal dialysis (PD)-associated peritonitis after the occurrence of exit-site infection (ESI) is limited. We aimed to investigate the association between ESI and the subsequent risk of PD-associated peritonitis. Methods: We conducted a multicenter, retrospective cohort study of adult incident PD patients in Thailand between January 2006 and September 2022. We compared matched pairs (1:1) of individuals who experienced the first episode of ESI with their counterparts who did not experience any ESIs during follow-up. The subsequent risk of PD-associated peritonitis was assessed using multivariable Cox proportional hazards models with shared frailty correction to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Landmark analysis corresponding to the designed landmark time after ESI was conducted (within 1 month, 1-3 months, 3-6 months, 6-9 months, and 9-12 months). Secondary analyses explored causative organisms and ESI severity. An ancillary meta-analysis of all available evidence was summarized using a random-effect model. Results: Among 5,368 incident PD cases in the cohort, a total of 610 patients were eligible, including 305 incident cases of the first episode of ESI and 305 corresponding matched index cases. The study cohort had a mean age of 59.3 years; most patients were male (56.7%), and most received continuous ambulatory PD (89.0%). Regarding adjustment for sociodemographic and clinical characteristics, PD practices, and laboratory profiles, the risk of subsequent PD-associated peritonitis was significantly increased among individuals who had experienced an ESI (HR, 5.30; 95% CI, 3.75-7.50). Following landmark analysis, the risk of PD-associated peritonitis increased at peak approximately 18-fold (within 1 month) and gradually decreased to 2-fold over the designed 9-12 months. Secondary analyses revealed consistent findings across the causative organism and severity strata of ESIs (HRs ranging from 5.17 to 5.98). An ancillary meta-analytic synthesis supported the main findings [3 included cohort studies; Conclusion: Regarding retrospective cohort analysis with ancillary meta-analytical synthesis, individuals experienced with ESI are at risk of developing PD-associated peritonitis. Effective strategies to prevent PD-associated peritonitis following an ESI episode are warranted to promote patient health and sustainable PD programs.
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