ReviewFrontiers in bioengineering and biotechnology2026
Mechanical memory in cells: mechanisms, effects, and applications in regenerative medicine.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Mechanical memory is the ability of cells to retain information from past mechanical environments, which profoundly influences cellular behaviour and fate, particularly in stem cells. This review combines contemporary insights into mechanical memory with specific attention to its underlying processes, which span mechanotransduction to epigenetic alterations. Various approaches to study mechanical memory have been investigated through substrate stiffness modulation, shear stress, and cyclic strain while evaluating the impact of mechanical memory on several cell types. Applications in regenerative medicine are discussed, including stem cell expansion, tissue engineering, and disease treatment. Future research directions are proposed to enhance the understanding and control of mechanical memory for therapeutic advancements, addressing gaps in molecular mechanisms and clinical translation.
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