Evidence map›Paper›PMID 42656735›Full record

ArticleFrontiers in immunology2026

BCG overexpressing Ag85B reprograms host immune response through coordinated transcriptional networks.

Vivek Chauhan, Rakesh Kumar, Raja Veerapandian, Enrique I Ramos, Chinnaswamy Jagannath, Shrikanth S Gadad, Subramanian Dhandayuthapani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antigen 85B ofVaccines · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vivek ChauhanCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States.
Rakesh KumarCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States.
Raja VeerapandianCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States.
Enrique I RamosDepartment of Biology, University of Texas El Paso, El Paso, TX, United States.
Chinnaswamy JagannathDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute & Weill Cornell Medical College, Houston, TX, United States.
Shrikanth S GadadSouth Texas Center of Excellence in Cancer Research and Department of Medicine and Oncology, School of Medicine, The University of Texas Rio Grande Valley, Edinburg, TX, United States.
Subramanian DhandayuthapaniCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States.

Funding

Novel Stem Cell Immunotherapy for MDR-TuberculosisR01AI161015 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ENDSLEY, JANICE J, JAGANNATH, CHINNASWAMY · 2021 to 2025
$4.8M
Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in MacrophagesR01AI184551 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Janice J Endsley, Chinnaswamy Jagannath · 2024 to 2026
$3.8M
Regulation of innate immunity by self-adjuvated MRNA vaccinesR01AI184394 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI JAGANNATH, CHINNASWAMY · 2025 to 2025
$2.7M
A Novel Hyper-Immunogenic Low Virulent BCG vaccine against TuberculosisR01AI175837 · NIAID · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI SUBRAMANIAN DHANDAYUTHAPANI · 2023 to 2026
$2.0M
Molecular basis of BCG vaccine sub-strain heterogeneityR01AI187440 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Jeffrey D. Cirillo, Chinnaswamy Jagannath · 2025 to 2026
$1.5M
Analysis of Divergent Transcripts in Estrogen-Dependent SignalingR16GM149497 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Shrikanth Gadad · 2023 to 2026
$620k
NIAID NIH HHS R01 AI161015NIAID NIH HHS R01 AI175837NIAID NIH HHS R01 AI184394NIAID NIH HHS R01 AI184551NIAID NIH HHS R01 AI187440NIGMS NIH HHS R16 GM149497
6 · The paper itself

Abstract

Antigen 85B (Ag85B), an immunodominant protein secreted by

Indexed as

AcyltransferasesAntigens, BacterialBacterial ProteinsBCG VaccineGene Regulatory NetworksMycobacterium bovisMycobacterium tuberculosisTuberculosisAnimalsFemaleGene Expression ProfilingMiceSignal TransductionSpleenAcyltransferasesantigen 85B, Mycobacterium tuberculosisAntigens, BacterialBacterial ProteinsBCG VaccineAg85Bantigen presentationcytokine signalingimmunometabolismM. tuberculosisrecombinant BCGRNA-seqT-cell differentiation

Identifiers

PMID42656735
PMCPMC13506869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.