Dual regulation of inflammation and ferroptosis: An injectable hydrogel targeting macrophages for the treatment of temporomandibular joint osteoarthritis and knee osteoarthritis.

Guangxin Sun, Shuze Wang, Zhenning Li, Xuzhuo Chen, Wei Wang, Linxi Zhou

Abstract read

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Guangxin SunLiaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, Liaoning, 110001, China.

Shuze WangLiaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, Liaoning, 110001, China.

Zhenning LiLiaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, Liaoning, 110001, China.

Xuzhuo ChenDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Wei WangLiaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, Liaoning, 110001, China.

Linxi ZhouDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis is a common progressive inflammatory degenerative joint disease that causes persistent pain and functional disability. Current treatments are insufficient to halt disease progression; therefore, elucidating the underlying molecular mechanisms and developing targeted local drug delivery systems that intervene in critical pathological nodes are of great clinical significance. This study developed a novel injectable hydrogel drug delivery system (DA-HAMA) based on Hyaluronic acid Methacryloyl (HAMA) to achieve local, sustained-release, and targeted delivery of the small-molecule drug Diminazene aceturate (DA) within the osteoarthritic joint cavity. The study first identified Spermidine/spermine N1-acetyltransferase 1 (SAT1) as a key potential target for inflammation and ferroptosis in OA synovial macrophages through bioinformatics analysis. It further demonstrated that its inhibitor DA effectively suppresses macrophage inflammatory responses and ferroptosis processes

Indexed as

Diminazene aceturateFerroptosisHydrogelInflammationOsteoarthritisSAT1Temporomandibular joint

Identifiers

PMID42656724

DOI10.1016/j.mtbio.2026.103565

PMCPMC13507843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.