Evidence map›Paper›PMID 42656701›Full record

ArticleFrontiers in pharmacology2026

Differential regulation of neutrophil degranulation by p38 MAPK and mitochondrial ROS during

Isabella Forasteiro Tavares, Rafaela de Souza Andrade, Natasha Cabral, Roberta Olmo Pinheiro, Veronica Schmitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabella Forasteiro TavaresFundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hanseníase, Rio de Janeiro, Brazil.
Rafaela de Souza AndradeFundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hanseníase, Rio de Janeiro, Brazil.
Natasha CabralFundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hanseníase, Rio de Janeiro, Brazil.
Roberta Olmo PinheiroFundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hanseníase, Rio de Janeiro, Brazil.
Veronica SchmitzFundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hanseníase, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Erythema Nodosum Leprosum (ENL) is an inflammatory complication of leprosy that is associated with the progression of peripheral nerve damage and the resultant physical disabilities. Neutrophil-mediated inflammation plays a crucial role in the emergence of ENL. Recent evidence suggests that Methods: To explore the mechanisms underlying inflammation Results: We found that at least 8 h of Discussion: These results indicate that p38 MAPK pathway and mitochondrial ROS production are important contributors to

Indexed as

inflammatory responseleprosylow density neutrophilsMycobacterium lepraeneutrophilic degranulation

Identifiers

PMID42656701
PMCPMC13506804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.