ReviewFrontiers in pharmacology2026
From bench to bedside: experimental pharmacology approaches to overcome bioavailability, stability, and translational barriers of bioactive peptides from natural sources.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Bioactive peptides derived from natural sources (marine organisms, plants, microbes, and fermented foods) exhibit potent antimicrobial, antihypertensive, antioxidant, and anticancer activities. However, their clinical translation is severely hindered by poor oral bioavailability, rapid proteolytic degradation, suboptimal pharmacokinetic profiles, and inconsistencies in sourcing and standardization. Objective: This review critically examines experimental pharmacology strategies to overcome these translational barriers, including Key findings: Most unmodified natural peptides display apparent permeability coefficients below Conclusion: Rigorous experimental pharmacology, rather than bioactivity alone, is the key to bridging the bench-to-bedside gap for natural bioactive peptides. A standardized translational workflow from discovery to IND filing is proposed to accelerate clinical application of these promising molecules.
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