Evidence map›Paper›PMID 42656680›Full record

ArticleGastro hep advances2026

Risk Factors for Pouch Neoplasia in Patients With Inflammatory Bowel Disease: A Case-Control Study.

Shanshan Wang, Huaibin Mabel Ko, Dana J Lukin, Marco Bertucci Zoccali, Usama Ahmed Ali, Ravi P Kiran, Ellen J Scherl, Bo Shen

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In one paragraph

Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shanshan WangCenter of Inflammatory Bowel Disease and the Global Center for Integrated Colorectal Surgery and IBD Interventional Endoscopy, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York.
Huaibin Mabel KoDepartment of Pathology and Cell Biology, Columbia University Medical, Center/New York Presbyterian Hospital, New York, New York.
Dana J LukinJill Roberts Center for Inflammatory Bowel Disease, Gastroenterology and Hepatology, Department of Medicine, New York Presbyterian/Weill Cornell Medical Center, New York, New York.
Marco Bertucci ZoccaliCenter of Inflammatory Bowel Disease and the Global Center for Integrated Colorectal Surgery and IBD Interventional Endoscopy, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York.
Usama Ahmed AliCenter of Inflammatory Bowel Disease and the Global Center for Integrated Colorectal Surgery and IBD Interventional Endoscopy, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York.
Ravi P KiranCenter of Inflammatory Bowel Disease and the Global Center for Integrated Colorectal Surgery and IBD Interventional Endoscopy, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York.
Ellen J ScherlJill Roberts Center for Inflammatory Bowel Disease, Gastroenterology and Hepatology, Department of Medicine, New York Presbyterian/Weill Cornell Medical Center, New York, New York.
Bo ShenCenter of Inflammatory Bowel Disease and the Global Center for Integrated Colorectal Surgery and IBD Interventional Endoscopy, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Patients with inflammatory bowel disease (IBD) undergoing total proctocolectomy with ileal pouch-anal anastomosis remain at risk of pouch neoplasia. Prior studies, based on cohorts ending in the 2010s, identified prior colorectal dysplasia and carcinoma as independent risk factors. We aimed to reassess contributors from a contemporary, prospectively maintained registry. Methods: Patients with an ileal pouch and underlying IBD were identified from tertiary centers (2019-2026) for a case-control study. Seventeen patients with pouch neoplasia were randomly matched 1:3 to 51 patients without pouch neoplasia. Pediatric patients (<18 years) and non-IBD pouches were excluded. Univariate and multivariable analyses were performed. Results: Among 748 patients, 17 (2.3%) had pouch neoplasia, including 1 (5.9%) with anal intraepithelial neoplasia grade 1, 3 (17.6%) with low-grade dysplasia, 4 (23.5%) with high-grade dysplasia, and 10 (58.8%) with cancer. Five patients were diagnosed with anal squamous neoplasia, of whom 4 (80.0%) tested positive for anal human papillomavirus. On multivariable analysis, dysplasia and carcinoma in the colectomy specimen were identified as independent risk factors for pouch neoplasia (adjusted odds ratio, 6.2; 95% confidence interval, 1.1-36.7; Conclusion: The presence of dysplasia or carcinoma in the colectomy specimen remains the strongest risk factor for pouch neoplasia. An unusual prevalence of anal squamous neoplasia was observed, with a notable presence of human papillomavirus infection.

Indexed as

Inflammatory Bowel DiseasePouch NeoplasiaRisk Factor

Identifiers

PMID42656680
PMCPMC13507545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.