Evidence map›Paper›PMID 42656666›Full record

ArticleNeurobiology of stress2026

Autonomic and limbic system functioning, early life stress, and depressive symptoms in adolescence.

Eugenia Giampetruzzi, Chase Antonacci, Jean Rachel Bahk, Jessica L Buthmann, Yoonji Lee, Katharina Kircanski, Ian H Gotlib

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eugenia GiampetruzziDepartment of Psychology, 450 Jane Stanford Way, Building 420, Stanford, CA, 94305, USA.
Chase AntonacciDepartment of Psychology, 450 Jane Stanford Way, Building 420, Stanford, CA, 94305, USA.
Jean Rachel BahkDepartment of Psychology, 450 Jane Stanford Way, Building 420, Stanford, CA, 94305, USA.
Jessica L ButhmannDepartment of Psychology, 450 Jane Stanford Way, Building 420, Stanford, CA, 94305, USA.
Yoonji LeeDepartment of Psychology, 450 Jane Stanford Way, Building 420, Stanford, CA, 94305, USA.
Katharina KircanskiDepartment of Psychology, University of Southern California, 3620 S. McClintock Ave, Los Angeles, CA, 90089, USA.
Ian H GotlibDepartment of Psychology, 450 Jane Stanford Way, Building 420, Stanford, CA, 94305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adolescence is a critical window for autonomic and limbic development and a period of elevated risk for depression. Although autonomic and limbic system function have, independently, been linked to depression, they are coupled and both influenced by early life stress (ELS). We do not yet know, however, whether the association of autonomic activity and limbic connectivity with depressive symptoms differs across dimensions of ELS. Methods: Participants were 93 youth (M Results: Greater RespHRV during recovery was associated with more negative right hippocampal tail-left lateral amygdala connectivity (β = -0.42, Conclusions: Whether autonomic-limbic coupling buffers or confers risk for depression depends on the early environment in which it developed.

Indexed as

Adolescent depressionAmygdalaEarly life stressHeart rate variabilityHippocampusNeurovisceral integration

Identifiers

PMID42656666
PMCPMC13507736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.