ArticleCurrent therapeutic research, clinical and experimental2026
U-Shaped Association Between Serum Vitamin B12 and All-Cause Mortality in Adults With Obesity in the United States: A Prospective Cohort Study.
Article in Current therapeutic research, clinical and experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Despite the health benefits of vitamin B12, the potential association between vitamin B12 and all-cause mortality in populations with obesity remains understudied. Objective: To dissect this intrinsic association in adults with obesity and identify potential threshold effects. Methods: Data from 1999 to 2006 and 2011 to 2014 were retrieved from the National Health and Nutrition Examination Survey database. Three models were developed by adjusting for demographic characteristics, clinical factors, and comorbidities, and the relationship between vitamin B12 and all-cause mortality was further analyzed using Cox proportional hazards modelling, restricted cubic spline, survival curve analysis, and threshold effect analysis. Results: Among 8301 participants with 1347 all-cause mortality over median follow-up of 9.08 years, the lowest groups Q1, Q2 and the highest group Q5 showed significantly increased all-cause mortality risk, although the Conclusions: All-cause mortality in the population with obesity showed an approximately U-shaped association with serum vitamin B12 levels. Maintaining serum B12 levels within 300 to 500 pmol/L is associated with a lower mortality risk. Owing to its observational design, causality cannot be inferred. Dynamic monitoring of vitamin B12 levels may help identify individuals at increased risk; however, further studies are needed to establish causality.
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