SynthesisFrontiers in medicine2026
Global research trends in embryonic mosaicism and mosaic embryo transfer: a bibliometric and science-mapping analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Embryonic mosaicism has emerged as a clinically significant topic in assisted reproductive technologies following the widespread adoption of preimplantation genetic testing for aneuploidy (PGT-A). This study aimed to characterize the global research landscape, identify major contributors, and delineate emerging thematic trends in mosaic embryo research using bibliometric and science mapping approaches. Methods: We conducted a bibliometric and science mapping analysis of original research articles and reviews published between 1990 and 2025 that focused on embryonic mosaicism, mosaic embryos, mosaic embryo transfer, or PGT-A-related mosaicism in reproductive medicine. Publication trends, citation impact, collaboration networks, and thematic evolution were analyzed using Bibliometrix and VOSviewer. Results: We included 394 eligible original research and review articles on embryonic mosaicism, mosaic embryo transfer, or PGT-A-related mosaicism in reproductive medicine, revealing a marked acceleration in research activity after 2015. The United States led in both publication volume ( Conclusion: This bibliometric analysis of 394 publications spanning 36 years demonstrates sustained, accelerating growth in research output since 2015, driven by the clinical adoption of NGS-based PGT-A and the subsequent dissemination of major professional society guidelines. The field has evolved from cytogenetic characterization to a clinically integrated discipline that directly informs embryo selection and IVF decision-making. Significant knowledge gaps persist regarding mosaicism thresholds, self-correction mechanisms, and long-term neonatal outcomes, underscoring the need for prospective registries and standardized reporting frameworks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.