ArticleNAR cancer2026
SNHG family lncRNAs promote Ewing sarcoma cell fitness through intronic snoRNA-guided rRNA modifications.
Marcela Briones-Martin-Del-Campo, Alex G Lee, Truc Dinh, Virginie Marchand, Yuri Motorin, Marta Román, Qiuli Bi, Stanley G Leung, Max A Horlbeck, Leanne C Sayles and 4 more
Abstract read
In one paragraphArticle in NAR cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Alex G LeeDepartment of Pediatrics, University of California, San Francisco, CA 94158, United States.
Truc DinhDepartment of Pediatrics, University of California, San Francisco, CA 94158, United States.
Virginie MarchandEpitranscriptomics and RNA Sequencing Core Facility, Université de Lorraine, CNRS, INSERM, IBSLor (UAR2008/US40), Nancy F-54000, France.
Marta RománDepartment of Pediatrics, University of California, San Francisco, CA 94158, United States.
Qiuli BiDepartment of Pediatrics, University of California, San Francisco, CA 94158, United States.
Stanley G LeungDepartment of Pediatrics, University of California, San Francisco, CA 94158, United States.
Leanne C SaylesDepartment of Pediatrics, University of California, San Francisco, CA 94158, United States.
Bo Kyung Alex SeongDepartment of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, United States.
Luke GilbertDepartment of Urology, University of California, San Francisco, CA 94158, United States.
Funding
Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7MSweet-Cordero_Diversity Supplement_Due 03/30/18R01CA211657 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SWEET-CORDERO, ERIC ALEJANDRO · 2017 to 2021
$2.0MIllumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583kNCI NIH HHS P30 CA082103NCI NIH HHS R01 CA211657NIH HHS S10 OD028511
6 · The paper itselfAbstract
Over 90% of Ewing sarcomas (EWS) are driven by the EWS-FLI1 fusion oncoprotein. EWS-FLI1 acts as a pioneer transcription factor, altering the expression of hundreds of genes including many long non-coding RNAs (lncRNAs). The role of these lncRNAs in the oncogenesis of EWS is mostly unknown. We developed a CRISPR interference (CRISPRi) strategy to knock down expression of lncRNA loci expressed in EWS and evaluate their effect on proliferation
Indexed as
Bone NeoplasmsRNA, Long NoncodingRNA, Small NucleolarSarcoma, EwingAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansIntronsMiceOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSRNA Processing, Post-TranscriptionalEWS-FLI fusion proteinOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSRNA, Long NoncodingRNA, Small Nucleolar
Identifiers
PMID42656604
PMCPMC13507652
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