ArticleJCEM case reports2026
Pregnancy-induced Cushing syndrome mediated by overexpressing
Article in JCEM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Pregnancy-induced Cushing syndrome (PICS), in which the onset of cortisol excess occurs during pregnancy with spontaneous remission postpartum, is a rare entity with serious maternal and fetal consequences. We describe the case of a 31-year-old woman who presented with pre-eclampsia at 24 weeks gestational age and florid features of hypercortisolism. Investigations revealed gross elevation of serum cortisol with absent diurnal rhythm, elevated 24-hour urinary free cortisol and suppressed adrenocorticotropic hormone. She required an emergency cesarean section for intrauterine fetal demise, attributed to placental abruption. Postpartum, she had normalization of serum cortisol and 24-hour urinary free cortisol, and late-night salivary cortisol was normal. Computed tomography scan showed bilateral adrenal micronodules. Additional investigations showed nonsuppressed cortisol after 1 and 8 mg dexamethasone. Moreover, serum cortisol increased 129% after stimulation with human chorionic gonadotropin. She underwent left adrenalectomy, with pathology indicating micronodular adrenocortical disease. Reverse transcription-polymerase chain reaction analysis showed an increased expression of
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