Trial reportFrontiers in nutrition2026
IgG positive food elimination diet altered gut microbiota, decreased zonulin in migraine adults: a pilot dietary intervention trial.
Trial report in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Gut microbiota and intestinal permeability may play a role in food specific IgG antibodies mediated delayed hypersensitivity in migraine patients. We aimed to evaluate the effect of food specific IgG-guided elimination strategy by assessing the changes in gut microbiota, zonulin as well as their correlation with symptoms, IL-6, TNF-α and CGRP. Methods: The study included 52 migraine patients in true diet group (excluding IgG positive foods) and 46 controls in sham diet group (excluding alternative IgG negative foods). The gut microbiota were evaluated by the 16S rRNA amplicon sequencing. Relative abundance analyses, α-diversity and β-diversity were implemented using QIIME 2. Zonulin, IL-6, TNF-α and CGRP was assessed using ELISA. Questionnaire surveys were used to investigate symptoms of migraine and its comorbidities. Results: At the end of 12 weeks, there were significant differences in β-diversity and the Simpson index (α-diversity) of gut microbiota in the true diet group. The relative abundance of Bacteroidetes decreased while that of Firmicutes as well as Bifidobacterium and Butyricicoccus increased in the true diet group. The true diet group had a larger reduction in zonulin compared to the sham diet group. The changes after the true diet of the relative abundance of certain gut microbiota were significantly correlated with MSQ, PSQI, IL-6, CGRP and zonulin. Conclusion: IgG positive food elimination diet altered gut microbiota, which was associated with decreased zonulin, CGRP and IL-6, and improvements in migraine and sleep. Clinical trial registration: Chinese Clinical Trial Registry (Chictr.org.cn, identifier ChiCTR2000039278).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.