Evidence map›Paper›PMID 42656532›Full record

ArticleFrontiers in immunology2026

Chronic TLR7 activation promotes expansion of activated CD11c

Fernando N Ferreyra, Laura Almada, Maria S Martinez, Yair A Chocobar, Rubén D Motrich, Juan Pablo Mackern-Oberti, Adriana Gruppi, Virginia E Rivero

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fernando N FerreyraFederation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.
Laura AlmadaFederation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.
Maria S MartinezFederation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.
Yair A ChocobarFederation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.
Rubén D MotrichFederation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.
Juan Pablo Mackern-ObertiInstituto de Medicina y Biología Experimental de Cuyo (IMBECU), Centro Científico Tecnológico (CCT) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina.
Adriana GruppiFederation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.
Virginia E RiveroFederation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-associated B cells (ABCs) have emerged as a distinct B cell population associated with aging, chronic inflammation, and autoimmunity. Notably, the expansion of ABC-like CD11c-expressing B cells has been observed in patients with systemic lupus erythematosus and in experimental models of lupus-like disease, suggesting their potential involvement in disease pathogenesis. Although their relevance in autoimmunity is increasingly appreciated, the identity and functional contribution of CD11c

Indexed as

AutoimmunityB-LymphocytesCD11c AntigenImmunity, HumoralLupus Erythematosus, SystemicMembrane GlycoproteinsToll-Like Receptor 7AnimalsAutoantibodiesB-Lymphocyte SubsetsDisease Models, AnimalFemaleImiquimodLymphocyte ActivationMiceMice, Inbred C57BLAutoantibodiesCD11c AntigenImiquimodMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7Toll-Like Receptor AgonistsABC-likeADORA2AautoantibodiesDN CD11c+ B cellsextrafollicular responseimiquimodlupusTLR7

Identifiers

PMID42656532
PMCPMC13506905

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.