ArticleFrontiers in aging neuroscience2026
MTHFR C677T and A1298C polymorphisms in dementia susceptibility: evidence from a meta-analytic investigation with disease-specific and ethnicity-stratified analyses.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Alzheimer's disease (AD) and vascular dementia (VaD) have become significant global health challenges. Recent research evidence indicates a close comorbidity between AD and cerebral small vessel disease. The C677T (rs1801133, also known as c.665C > T) and A1298C (rs1801131) polymorphisms in the methylenetetrahydrofolate reductase ( Methods: We conducted a systematic search of PubMed, Embase, Web of Science and the Cochrane Library, covering the period from the inception of these databases to January 2026. Studies reporting the distribution of Results: A total of 26 C677T studies and 8 A1298C studies were included. In the allele contrast model (T vs. C), C677T was significantly associated with dementia (OR = 1.40, 95% CI 1.05-1.87, Conclusion: This meta-analysis showed that the
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