ArticleFrontiers in cellular and infection microbiology2026
A preliminary exploration of the mechanism of endometrial cancer development induced by intestinal flora diversity and its metabolites.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endometrial cancer (EC) is a highly prevalent gynecological malignancy increasingly affecting younger populations. While the gut microbiota significantly modulates tumor progression via organ-to-organ networks, the specific molecular mechanisms and microbial co-metabolites driving EC remain poorly understood. This study profiles gut microbiota alterations in EC patients to identify correlations between microbial lipid/bile acid metabolites and EC pathogenesis. Methods: A clinical cohort of 41 female participants (17 patients with histologically confirmed atypical endometrial hyperplasia or endometrioid adenocarcinoma, and 24 healthy controls) was prospectively enrolled. Fecal and serum samples underwent 16S rRNA gene sequencing (Illumina MiSeq) and LC-MS-based serum metabolomics, respectively. Spearman correlation analysis explored gut microbiota-metabolite associations. Results: The EC and control groups shared structural similarities, but the Conclusions: This study delineates distinct alterations in the gut microbiota and serum metabolomic profiles of EC patients, identifying
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