ArticleFrontiers in aging neuroscience2026
Stage-dependent clinical burden in hospitalized Parkinson's disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Orthostatic hypotension (OH) is common in Parkinson's disease (PD), but what is known of its clinical associations comes from ambulatory or population-based cohorts assessed under protocolised or tilt-table conditions. The patients whom a routine bedside screen identifies on a general ward have not been described. Objective: To characterise the modified Hoehn-Yahr (H-Y) stage distribution of hospitalized PD patients with a positive bedside OH screen, and to describe how clinical burden is distributed across stage within that group. Methods: Retrospective cross-sectional analysis of 125 consecutive adults admitted to a Chinese tertiary neurology department (January 2021 to March 2025) with idiopathic PD and a positive bedside OH screen, defined as a fall of ≥20 mmHg systolic or ≥10 mmHg diastolic at 1 or at 3 min upright. No OH-negative comparator was available. The primary outcome was the H-Y stage distribution; secondary outcomes were motor severity (MDS-UPDRS Part III), motor complications, fracture history, physician-documented sleep disturbance and length of stay. Stage groups were compared using rank-based tests with effect sizes, with multivariable and Firth penalized logistic regression for the two principal binary outcomes. Results: Screen-positive inpatients spanned the whole H-Y spectrum: 42.4% (95% CI 34.1-51.2) were at H-Y 1.0-2.0, before postural instability. One third (33.6%, 95% CI 25.9-42.3) met the criterion at 1 min only and would not have been detected by a 3-min-only rule. Motor severity rose steeply across stage (median MDS-UPDRS Part III 18, 35 and 62.5; Conclusion: A bedside OH screen identifies a clinically heterogeneous inpatient group that is not confined to advanced disease, and a third of it is detectable only at 1 min. Because all participants were screen-positive, these comparisons describe that group and cannot establish that the screening result marks burden independently of stage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.