ArticleFrontiers in cellular neuroscience2026
Stress-responsive nucleus accumbens dopamine D2 receptor-expressing neurons modulate cocaine-induced behavioral sensitization.
Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although both stress and cocaine induce robust plasticity within the nucleus accumbens core (NAcc), how these distinct experiences interact at the cellular level to shape behavior remains unclear. Here, we investigated the role of NAcc dopamine D2 receptor-expressing medium spiny neurons (D2R-MSNs) in integrating stress- and drug-induced signals. D2R-MSNs showed distinct activity responses, with increased activity during restraint stress and reduced activity following repeated cocaine exposure. Using the Cre-dependent Robust Activity Marking (cRAM) system, we found that cocaine exposure suppressed the activity of the subpopulation of D2R-MSNs previously recruited by stress. Optogenetic reactivation of these stress-tagged D2R-MSNs during withdrawal attenuated the expression of cocaine-induced behavioral sensitization. Transcriptomic profiling of stress-responsive D2R-MSNs identified cholecystokinin (
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