Evidence map›Paper›PMID 42656335›Full record

ArticleFrontiers in medicine2026

Reflux esophagitis patients exhibit reduced gastric tolerance, impaired slow-wave activity and esophageal dysmotility.

Yi Yang, Xueying Yin, Xiaoyan Wang, Jing Zhang, Jun Yu, Fengming Yue, Lixia Wang, Dong Yang, Zhifeng Zhang, Xiaoyu Sun and 2 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yi Yang *The Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Xueying Yin *The Third Department of Gastroenterology, Affiliated Central Hospital of Dalian University of Technology, Dalian, China.
Xiaoyan Wang *The First Ultrasound Department, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Jing ZhangThe Third Department of Gastroenterology, Affiliated Central Hospital of Dalian University of Technology, Dalian, China.
Jun YuThe Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Fengming YueThe Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Lixia WangThe Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Dong YangThe Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Zhifeng ZhangThe Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Xiaoyu SunThe Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Xiukun HouThe First Ultrasound Department, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Zhijun DuanThe Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Reflux esophagitis (RE) is an endoscopic subtype of gastroesophageal reflux disease (GERD). Although gastric dysfunction is known to contribute to GERD, a comprehensive assessment of gastric motor function specifically in RE patients remains lacking. Objective: To comprehensively evaluate gastric motor function in patients with reflux esophagitis (RE) using a multidimensional non-invasive protocol, and to explore the associations between gastric motility abnormalities and esophageal dysmotility. Methods: Forty RE patients diagnosed by endoscopy and high-resolution manometry (HRM) and 34 healthy controls were enrolled between April 2019 and January 2020 based on feasibility of recruitment during the study period. Gastric tolerance and visceral sensitivity were evaluated using a nutrient drink test combined with a visual analog scale (VAS). Gastric emptying was assessed by gastrointestinal ultrasound, and gastric myoelectrical activity was recorded by electrogastrography (EGG). Esophageal motility was simultaneously evaluated by HRM. Results: Compared with controls, RE patients showed significantly reduced maximum tolerated volume (MTV), higher postprandial VAS scores for fullness, nausea and pain, lower gastric emptying rates at 20 and 30 min postprandially, and a lower percentage of normal postprandial slow waves (all Conclusion: RE patients exhibit multiple gastric motility abnormalities, including reduced gastric tolerance, visceral hypersensitivity, delayed gastric emptying, and postprandial gastric dysrhythmia. These gastric dysfunctions are associated with typical RE symptoms and selectively correlate with esophageal contractile indices, suggesting that RE may represent a disorder of upper gastrointestinal motility.

Indexed as

esophageal motilitygastric motilitymulti-dimensional evaluationreflux esophagitisvisceral hypersensitivity

Identifiers

PMID42656335
PMCPMC13506367

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